Max Bergmann lecture Protein epitope mimetics in the age of structural vaccinology
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Max Bergmann lecture Protein epitope mimetics in the age of structural vaccinology‡
This review highlights the growing importance of protein epitope mimetics in the discovery of new biologically active molecules and their potential applications in drug and vaccine research. The focus is on folded β-hairpin mimetics, which are designed to mimic β-hairpin motifs in biologically important peptides and proteins. An ever-growing number of protein crystal structures reveal how β-hai...
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Macromolecular structures represent an interesting starting point for the design and synthesis of small-molecule mimetics of surface epitopes that mediate protein-protein and protein-nucleic acid interactions. The resulting protein epitope mimetics (PEMs) provide a source of new biologically active molecules that are useful as biomolecular probes in chemical biology, as well as novel drug or va...
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There is growing interest in the design of synthetic molecules that mimic the structures and functions of epitopes found on the surface of peptides and proteins. Epitope mimetics can provide valuable tools to probe complex biological processes, as well as interesting leads for drug and vaccine discovery. One application of epitope mimetics is reviewed here, focusing on mimetics of the cationic ...
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The isolation of two proteinases in crystalline form from extracts of beef pancreas has been described by Kunitz and Northrop (1). These enzymes have been named trypsin and chymotrypsin. Previous publications (2) from this laboratory have reported the finding of a series of synthetic peptide derivatives which were readily hydrolyzed by crystalline chymotrypsin. In this communication a synthetic...
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ژورنال
عنوان ژورنال: Journal of Peptide Science
سال: 2013
ISSN: 1075-2617,1099-1387
DOI: 10.1002/psc.2482